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[ 3.240812398895283, -1.5373084456298136, -0.4985865229069666],

In 2009, PacBio published a paper expanding the principle into a full-blown sequencing technique. Once again, each nucleotide was labeled with a different colored fluorophore detectable by the ZMW to determine which base had been incorporated. The fluorophores were attached such that they would be cleaved off during the chemical reaction incorporating the base into the growing DNA strand; they would then diffuse out of the ZMW so that the next fluorophore could be detected. Sequencing took place on a chip with many wells simultaneously — a different type of parallelization where each well detected a single DNA molecule undergoing the same basic chemical reaction.

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Huh — the left-hand portion of the expression is the same as the formula for the error ε of approximating r using a rational fraction a / b. In other words, the inequality seems to be saying that, as a consequence of the pigeonhole principle, we can pick any r and any K 0, and there’s always some integer a / b that approximates r with an error of less than 1 / (K · b).

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Фото: Evgeniy Maloletka / AP

Минпромторг актуализировал список пригодных для работы в такси машин20:55,更多细节参见PDF资料